Content reuse is an important area of software engineering and information systems research. Key factors affecting systematic content reuse are the heterogeneous nature of digital encoded content; the need for ontological structures to coherently organise content for reuse, the need for workflow systems to facilitate content authoring, and the reality of continuous transformation that is demanded by regeneration and reuse of content. It is argued that the privileged focus on content reuse differentiates the Content Management System (CMS) from other information management systems, but that CMS products currently lack a systematic approach to the problem of content regeneration and reuse. This thesis develops a conceptual model directed by a set of principles to facilitate systematic content reuse addressing the underlying complexities of heterogenous media and presentational formats. It is argued that the axiom of separation of content, structure and presentational form must be realised not only in a document ontology but also in an information system architecture. A systematic approach to regeneration and reuse of digital multimedia requires a clear and comprehensive strategy on content composition, publishing runtime engine, information retrieval, and database management for loosely typed and unstructured data. This model is presented in four layers, each layer building in complexity on the lower layer, and each layer addressing specific aspects of the content regeneration and reuse problem. The Content Model for Reuse is explored through Software Development Research and a complex field trial. The results of a substantial field trial conducted over a three-year period are presented. The completeness of the model is evaluated against qualitative measures at each layer of the conceptual model. Measures for information currency and content reuse are defined and applied in the context of the field trial with results that indicate both better content currency over time and increased content reuse.